Now that you’ve got Ashley back, you’ll once again have to protect her in one of the most dangerous environments thatResident Evil 4 Remakehas to offer. This is a long chapter filled with memorable fights, but it’s easy for things to go wrong quickly. Stay sharp if you want to reach the Los Illuminados Sanctuary!

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Not only will this guide help you decide where to go and how to prepare, but we’ve also got strategies and tips for surviving the challenging battles in Chapter Fourteen. Keep it handy, and you’ll be on your way to the game’s climactic showdown in no time at all!

This guide contains spoilers.

How To Reach The Waste Treatment Plant

When the cutscene ends,grab everything you’re able to from the roomwhile Leon is talking to Ada. Be sure to get theCrystal Ore in the cornerand theBlack Bass in the cabinetbehind the cot. Leave the room andboost Ashley through the gap in the wall to the left.She’ll unbar the door, letting you move on to the next area.

Read the Merchant Request on the right, enter the Merchant’s Hideout. You cansell the Crystal Ore, Wrench and Keycardfor spare cash and take the elevator to the Shooting Gallery to try for some new Charms.

leon kennedy and ashley graham in the waste treatment plant in resident evil 4 remake

Leave through the doors to the left of the Merchant, andshoot as many crows as you canon the other side before they fly off to get some cash. Climb the stairs andjump off the ledge to the left. Two Ganados will attack from the corridor; the one in front spawns a Plaga when killed.

Follow the corridor that the Ganados came from andloop around counterclockwise.A third enemy is waiting at the bottom of the stairs; deal with him and climb up. At the top,take the Green Herb on the rightthen enter the building.

an iron maiden in resident evil 4 remake

You’ll be attacked by a gang of Ganados at the end of the hall. They have shields, and two of them will spawn Plagas, sohold your ground at the entranceand make good use of any grenades that you have on hand. When the room is clear,go up the stairs to the right.Enter the office at the end of the hall, take the supplies from the desk, andhave Ashley hold the lever on the left-hand wall.

Go back downstairs to go through the door that opens. you may alsoshoot the cask on the ceilingfor a Velvet Blue. On the other side of the door,turn leftand unlatch the door leading back to the main room.

leon kennedy watches ashley graham operate a crane with a wrecking ball in resident evil 4 remake

A new group of Ganados will arrive, beating you to Ashley’s location; get to her as quickly as possible to rescue her, then eliminate any remaining Ganados.

Return to the side hallway through the door that you unlatched andtake the stairs.More Ganados and Plagas will block your path; when you reach the top,go rightand enter the door you find.

a regenerador viewed through the biosensor scope in resident evil 4 remake

Loot the barrel at the far end of the room thenhop into the water on the left.Crouch through the small passage on the right andpick up the Emerald in the left cornerbefore climbing out of the sewage. Use the switches by the door; Leon and Ashley need toboth pull their respective switcheswhile the indicator above the door is in the red zone.

How To Defeat The Iron Maiden

Go through the door andhave Ashley hide in the locker ahead of you. Pick up the rifle ammo next to the locker andequip your rifle with the Biosensor Scopeif it’s not already there. As you go down the next hall, a Regenerador will emerge from the right. When you destroy all of its parasites, it will transform into an Iron Maiden with a final parasitein its head.Its movements are too erratic to line up a good shot with the scope, so tryshooting into its mouthwith the shotgun to destroy the final parasite.

The Iron Maiden will spasm before it finally dies; get as far away from it as you can, as it willexplode in a damaging burst of spikes.

osmund saddler, the fifteenth prophet of los illuminados in resident evil 4 remake

With the Regenerador dead, call Ashley out from hiding and open the next door, using the same method as before. The red zone is smaller, so you’ll need to be more precise with your input. Follow the corridor beyond andhave Ashley turn the wheelat the end to raise a bridge. Go across and turn left. Stay to the right side of the corridor to find some crates with ammo, andfollow the path until you find a power switch.

Look through the bars to the left - two Ganados will appear and attack Ashley. At the same time, aRegenerador will spawn on the pile of trash behind you.Equip your rifle with the Biosensor Scope and you canshoot out some parasitesbefore the Regenerador starts moving.

major jack krauser prepares to fight leon kennedy in resident evil 4 remake

Kill the Regenerador as quickly as you can - it will evolve into an Iron Maiden, so watch out - whileshooting the Ganados through the barsto defend Ashley. If she’s captured,pull back toward the switchand shoot the abducting Ganado as he makes a run for the exit.

When the Regenerador is dead,run back to the bridgeand take out any Ganados near Ashley so that she can raise the bridge for you, then go to the powered-up panel behind her. Calibrate the power and go through the door to keep moving. The correct sequence is:

major jack krauser’s mutant plaga form in resident evil 4 remake

1

2

3

4

Once you’re through the door, kill the twofree-roaming Plagasblocking the hallway and go through the door to find the Merchant.

Optional Objective: Even More Pest Control

Killing all the rats in the Waste Control area will fulfill a Merchant Request. The first rat isjust past the doorafter defeating the first Regenerador. The second isimmediately on the other side of the bridgethat Ashley raises. The third and fourth are bothnear the power switch, where you fight the second Regenerador.

How To Defend The Wrecking Ball

Once you’re done at the Merchant’s,jump down into the construction area ahead.Examine the wall with the crack in it, and Ashley will use the nearby equipment to smash it. While she’s working, you need todefend the machinefrom the oncoming Ganados.

Explore the area before interacting with the wrecking ball for extra items. There’s aFlash Grenade hidden among the equipment next to the vehiclethat’s especially useful in the upcoming fight!

Start bymoving to the other side of the vehicle- that’s where the door is, so the Ganados will attempt to break in through there. A single shot is all it takes to get them to fall off, so focus on fighting until you hear Ashley scream, them shoot whoever is on the machine. A shotgun blast right at the start of the fight canknock down the three Ganados in front of you, giving you time to run through the open shipping container to your left.

Two Brutes will appear throughout the first phase of the fight. Once they’re gone, you’ll have to contend with arocket launcherand a swarm of Plagas, plus the mob of Ganados. Use the Flash Grenade to kill the Plagas as soon as they appear - this will keep them from making the Ganados go berserk.

When Ashley breaks through the wall, mop up the remaining enemies and proceed through the opening. Look on a crate to the left to find a Merchant Request to eliminate a “strange corpse” in the Incubation Lab. you’re able to make your way back byunlatching the gate to the side, or ignore the side quest and activate the lift.

The gate takes you back to the Merchant’s Hideout, so be sure to gear up before going after this mini-boss. When you’re ready,return to Ashley’s holding celland retrace your path back to the Incubation Lab where you got the Biosensor Scope. There’s a locker along the way - have Ashley wait inside so that you’re able to fight without putting her in danger.

The Regenerador in the lab has already transformed, so expect it to hit you with lots of rapid needle bursts. Having your armor and knife at full durability going in is essential todeflect damage and escape grabs.Equip the Biosensor Scope on your rifle andtake out as many parasites as you can through the windowbefore closing to engage. This Regenerador has many more parasites than the others, so take careful aim! When you’re done,collect your reward from the Merchantand return to the lift.

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How To Pursue Saddler

At the top of the lift, enter the door on the right. Smash the barrels behind the machine in front of you, thenclimb through the window to your left.Loot the room, then exit through the rear doors. You’ll find yourself in a warehouse full of amber extracted from below the castle. Follow the path andexamine the large stone in the cornerto trigger a cutscene. Afterward,take the Yellow Herb from the shelf to the leftand look behind the shelf for a Crystal Ore, then follow Saddler through the double doors.

When you come to a fork in the road,look to the right.You can easily snipe the Ganado at the end of the tunnel without alerting the others, then use his vantage point to pick off the others. The left-hand path leads to the ground level if you prefer a more straight-up fight, but it’s worth taking the right-hand path for thesupplies andClockwork Castellanthat you can find there.

Loot the campsite, being sure to checkboth inside and behind the tent, and continue along the trail. Examine the documents in the command tent, thenfollow the blood trailout the back. Loot the barrels on the right, thenwalk through the archand save at the typewriter. The Merchant is also available for last-minute repairs. Proceed along the path until a cutscene triggers to begin the boss fight against Krauser.

How To Defeat Jack Krauser

Start the fight bywaiting for Krauser to empty his clip, then running to the left while he’s reloading. Crouch behind each pillar in succession to avoid Krauser’s fire, then duck into the ruins at the end of the path.

Crouch behind the wall to avoid another shot from Krauser, then enter the hallway at the rear of the room. At the top of the ramp, Krauser will rush you for a melee attack. Fight him like you did before,using knife parries and dodgesto avoid his attacks while slashing at him while he’s open. He’s faster this time, so be ready!

When Krauser jumps onto the rooftop above, he’s preparing an explosive round -get behind the pillar against the wallto avoid it!

Keep fighting until Krauser uses a Flash Grenade to retreat, thenturn the wheelto open the door in the room below. Use caution as you round the corner, since Krauser hasset up mines inside the ruins.Shoot them or crouch under their lasers as needed.

At the bottom of the stairs, there’s a crate with supplies - take them, thenimmediately turn aroundas Krauser is waiting to ambush you. He’ll grab you if he catches you, but you canhalt his charge by shooting himif you’re fast. After he retreats,detonate the mineblocking your path and continue.

If you ignore the crate, Krauser attacks when you leave the room instead. Unlike his attack at the crate, this grab can’t be avoided.

Rounding the next corner,stay behind the walluntil Krauser fires an explosive round. Afterward,stay to the extreme right side of the hallto avoid the bear trap in the shadows, thencarefully shoot around the next corner to the leftto detonate the mine.

The two hallways to the left are each covered byturrets on the ceiling.The only way through is toshoot them before they start firing.There are more bear traps on the ground to avoid as well. First, use the left-hand hallway to get a firing angle on the mine blocking the right side, then go down the other hallway to proceed.

Movevery slowlydown the curving hallway. This will give you time to react to the turret, bear trap, and Krauser’s shot at the very end of the passage. If you move too fast, you’ll walk into all three traps.

Climb the stairs andtake the Red Herb on the ledge ahead.There’s also a crate behind you and to the left that you’ll only notice if you turn around. Once you’ve collected everything, continue forward andrun up the stairsto stay ahead of another shot from Krauser.

At the top,immediately duck behind the nearest stone.After Krauser fires,shoot the mine on the rightthen duck back down. Wait for him to fire again, then run forward.

There are two sections of wall ahead -avoid the left one, as there’s a bear trap in front of it. When Krauser fires,run straight aheadand duck behind the next wall. There’s a Green Herb there that you can mix with the Red Herb you picked up in the previous room.

Keep to the right as you approach the stairs to keep Krauser from getting another shot. When you reach the bottom step, he’ll toss some grenades your way and then retreat.Shoot the mine on the rightand follow him.

You don’t have time to deal with the mine on the left in the next room, as Krauser willopen fire as soon as you enter.Get behind the pillar on the leftthen return fire until he jumps down. If you’re quick, you canshoot out the minebefore Krauser engages, saving yourself from having to worry about it during the fight.

Battle Krauser with knives again until a cutscene triggers. In the new area afterward,follow the corridoruntil Krauser appears andparry his lighting-fast melee attack.When he retreats, keep moving and get theYellow and Green Herbsalong the path. Shortly afterward, Krauser will attack from above -hit the timed Evade inputto avoid damage.

Loot the barrels on the left after Krauser’s attack, then climb the ladder to the final showdown.Evade Krauser againas the cutscene ends then hit him with everything you’ve got. You’ll still need to use parries and dodges to keep your Health from draining too quickly, but now you canuse your full arsenal without having to rely on knives.

There are a few crates on the side of the arena that you may use for emergency resupplies - just keep an eye on Krauser while you make your way to them!

When Krauser leaps to the top of the ruins,move to the edges.The closer you are to the center when he lands, the more damage you’ll take. Once he’s back on the ground,get away from the edgeto keep him from pushing you over. Once Krauser has taken sufficient damage in his final form the fight will end, and you’ll get his Fighting Knife, an exceptional melee weapon.

Loot the remaining crates in the area, thencross the drawbridgeto finish the chapter.